Endocrine Abstracts

Introduction: Leptin receptors have been identified in many peripheral tissues as well as the CNS including the hippocampus, which is particularly vulnerable in Alzheimer’s disease (AD). Animal data shows that leptin may be implicated in the pathophysiology of AD. The aim of this study was to examine if there is any differences in serum leptin levels between patients with AD and normal controls.Material and methods: Ninety patients with AD and 95 no...

Introduction: Alzheimer’s Disease (AD) is a multifactorial disease. The hypothalamo-pituitary–adrenal (HPA)-axis shows extensive changes in AD. It is observed a hyperactivation of corticotropin-releasing hormone (CRH) neurons with age, which is significantly present in men. The aim of this study is to compare serum levels of cortisol in patients with Alzheimer’s disease and normal controls.Material and Methods: Ninety patients with AD and ...